The liver diseases including viral hepatitis, drug induced hepatitis, cirrhosis and liver cancer is common in Taiwan. According the recent scientific literature, the regeneration of liver cell acts the important role to repair chemistry and biological injury, especially in liver cirrhosis, cancer, operation excision and transplant.
In order to understand the role of traditional chinese medicine in liver regeneration. This study drafts to explain the effects of qi-tonic and blood-tonic Chinese medicine recipes in liver regeneration.
120 rats were divided into five groups: sham, control, silymarin, si jun zi tang and si wu tang groups. All animals were submitted to oral administration of distilled water, silymarin and the aqueous extract of chinese medicine herbs, respectively. After a week, they underwent 2/3 partial hepatectomy. 3, 72 and 168 hours later, livers of each group were removed. Hepatic regeneration was assessed by liver/body weight ratio and immunohistochemical staining for PCNA and BrdU.
These results show that the qi-tonic chinese medicine si jun zi tang at oral doses of 1 g/kg causes a high liver regeneration rate in rats submitted to partial hepatectomy.
