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    Title: 補氣方劑(四君子湯)與補血方劑(四物湯)對大鼠部分肝切除後肝再生之影響;Effect of Chinese Medicine for Supplementing Qi and Blood on Liver Regeneration of Rat after Partial Hepatectomy
    Authors: 馬易世;Yi-Shih Ma
    Contributors: 中國醫藥大學:中國醫學研究所碩士班
    Keywords: 肝再生;部分肝切除;四君子湯;四物湯;補氣;補血;liver regeneration;partial hepatectomy;Chinese medicine;Qi;blood
    Date: 2007-07-25
    Issue Date: 2009-08-10 16:01:20 (UTC+8)
    Abstract: 肝病的相關研究,一直以來便是國內外研究的焦點。肝臟相關的疾病很多,但除了積極治療病因之外,肝細胞的再生與各種肝臟疾病的治療或復原亦有密切的關係。中醫擁有完整的治療理論,臨床上對於肝臟疾病的治療也擁有不錯的經驗與療效。而傳統中醫的治療理論架構於氣血之上,氣主煦之,血主濡之,兩者和個體的生存發育可說是息息相關的。其中,四君子湯為中醫補氣代表方劑,而四物湯則為中醫補血代表方劑,兩者亦是臨床常用的基礎方劑。
     因此本實驗便欲以四君子湯和四物湯作為研究對象,藉由肝重/體重比與內源性再生標記PCNA、外源性再生標記BrdU之免疫組織化學染色法,來評估兩者對於大鼠部分肝切除後的肝細胞再生是否具有促進之作用。
     結果發現,在中醫方劑促進部分肝切除後肝再生方面,不管是從肝重/體重比、PCNA GF、PCNA LI與BrdU LI都可發現,中醫補氣代表方劑四君子湯具有促進大鼠部分肝切除後肝再生的傾向,並且此促進作用應會在肝臟重量逐漸恢復後減緩。

    The liver diseases including viral hepatitis, drug induced hepatitis, cirrhosis and liver cancer is common in Taiwan. According the recent scientific literature, the regeneration of liver cell acts the important role to repair chemistry and biological injury, especially in liver cirrhosis, cancer, operation excision and transplant.
    In order to understand the role of traditional chinese medicine in liver regeneration. This study drafts to explain the effects of qi-tonic and blood-tonic Chinese medicine recipes in liver regeneration.
    120 rats were divided into five groups: sham, control, silymarin, si jun zi tang and si wu tang groups. All animals were submitted to oral administration of distilled water, silymarin and the aqueous extract of chinese medicine herbs, respectively. After a week, they underwent 2/3 partial hepatectomy. 3, 72 and 168 hours later, livers of each group were removed. Hepatic regeneration was assessed by liver/body weight ratio and immunohistochemical staining for PCNA and BrdU.
    These results show that the qi-tonic chinese medicine si jun zi tang at oral doses of 1 g/kg causes a high liver regeneration rate in rats submitted to partial hepatectomy.
    Appears in Collections:[Graduate Institute of Chinese Medical Science] Theses & dissertations

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