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| 題名: | Profound difference of metabolic pharmacokinetics between pure glycyrrhizin and glycyrrhizin in licorice decoction |
| 作者: | Hou, YC;Hsiu, SL;Ching, H;Lin, YT;Tsai, SY;Wen, KC;Chao, PDL |
| 貢獻者: | 藥學院藥學系;China Med Univ, Sch Pharm, Taichung 404, Taiwan;China Med Univ, Sch Chinese Med, Taichung 404, Taiwan;China Med Univ, Inst Chinese Pharmaceut Sci, Taichung 404, Taiwan;China Med Univ, Inst Pharmaceut Chem, Taichung 404, Taiwan;China Med Univ, Sch Cosmeceut, Taichung 404, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 18:56:18 (UTC+8) |
| 出版者: | PERGAMON-ELSEVIER SCIENCE LTD |
| 摘要: | Aloe-emodin (1,8-dihydroxy-3-(hydroxymethyl)-anthraquinone) is one of the active constituents from the root and rhizome of Rheum palmatum. Our previous study has demonstrated that aloe-emodin induced a significant change in the expression of lung cancer cell apoptosis-related proteins compared to those of control cells. However, the molecular mechanisms underlying the biological effects of aloe-emodin still remain unknown. Based on these reasons, we were interested in the change of aloe-emodin-induced total protein expression by the proteomics technique during aloe-emodin-induced lung cancer cell apoptosis. Our study applied 2D electrophoresis to analyze the proteins involved in aloe-emodin-induced apoptosis in H460 cells. We found that the release of nucleophosmin from the nucleus to the cytosol and the degradation of nucleophosmin were associated with aloe-emodin-induced H460 cell apoptosis. Our study also demonstrated that the gene expression of nucleophosmin remained unchanged after treatment with aloe-emodin. The aloe-emodin-caused increase in the amount of proform and fragment of nucleophosmin in cytoplasm may be one of the important events for aloe-emodin-induced H460 cell apoptosis. (C) 2004 Wiley-Liss, Inc. |
| 關聯: | LIFE SCIENCES 76(10):1167-1176 |
| 顯示於類別: | [藥學系暨碩博士班] 期刊論文
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