Profound difference of metabolic pharmacokinetics between pure glycyrrhizin and glycyrrhizin in licorice decoction

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 藥學院 > 藥學系暨碩博士班 > 期刊論文 > Item 310903500/31076

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题名:	Profound difference of metabolic pharmacokinetics between pure glycyrrhizin and glycyrrhizin in licorice decoction
作者:	Hou, YC;Hsiu, SL;Ching, H;Lin, YT;Tsai, SY;Wen, KC;Chao, PDL
贡献者:	藥學院藥學系;China Med Univ, Sch Pharm, Taichung 404, Taiwan;China Med Univ, Sch Chinese Med, Taichung 404, Taiwan;China Med Univ, Inst Chinese Pharmaceut Sci, Taichung 404, Taiwan;China Med Univ, Inst Pharmaceut Chem, Taichung 404, Taiwan;China Med Univ, Sch Cosmeceut, Taichung 404, Taiwan
日期:	2005
上传时间:	2010-09-24 18:56:18 (UTC+8)
出版者:	PERGAMON-ELSEVIER SCIENCE LTD
摘要:	Aloe-emodin (1,8-dihydroxy-3-(hydroxymethyl)-anthraquinone) is one of the active constituents from the root and rhizome of Rheum palmatum. Our previous study has demonstrated that aloe-emodin induced a significant change in the expression of lung cancer cell apoptosis-related proteins compared to those of control cells. However, the molecular mechanisms underlying the biological effects of aloe-emodin still remain unknown. Based on these reasons, we were interested in the change of aloe-emodin-induced total protein expression by the proteomics technique during aloe-emodin-induced lung cancer cell apoptosis. Our study applied 2D electrophoresis to analyze the proteins involved in aloe-emodin-induced apoptosis in H460 cells. We found that the release of nucleophosmin from the nucleus to the cytosol and the degradation of nucleophosmin were associated with aloe-emodin-induced H460 cell apoptosis. Our study also demonstrated that the gene expression of nucleophosmin remained unchanged after treatment with aloe-emodin. The aloe-emodin-caused increase in the amount of proform and fragment of nucleophosmin in cytoplasm may be one of the important events for aloe-emodin-induced H460 cell apoptosis. (C) 2004 Wiley-Liss, Inc.
關聯:	LIFE SCIENCES 76(10):1167-1176
显示于类别:	[藥學系暨碩博士班] 期刊論文

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