資料載入中.....
|
請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/31015
|
| 題名: | Marked decrease of cyclosporin absorption caused by coadministration of Cordyceps sinensis in rats |
| 作者: | Chiang, HM;Hou, YC;Tsai, SY;Yang, SY;Chao, PDL;Hsiu, SL;Wen, KC |
| 貢獻者: | 藥學院藥妝系;China Med Univ, Sch Cosmeceut, Taichung, Taiwan;China Med Univ, Sch Pharm, Taichung, Taiwan;China Med Univ, Sch Chinese Med, Taichung, Taiwan;China Med Univ, Inst Pharmaceut Chem, Taichung, Taiwan;Jen Teh Jr Coll Med Nursing & Management, Miaoli, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 18:53:19 (UTC+8) |
| 出版者: | NATL LABORATORIES FOODS DRUGS |
| 摘要: | Rutin and quercetin, a flavone glycoside and its aglycone, are the flavonoids most widely and abundantly present in herbs and plant foods. The aim of this study was to characterize and compare the bioavailability and metabolic pharmacokinetics of rutin and quercetin in rats. Quercetin was administered intravenously (33 mu mol/kg) and orally (165 mu mol/kg), while rutin was administered only orally (328 mu mol/kg) to rats. Blood samples were withdrawn via cardiopuncture at specific time points. An HPLC method was used to determine the concentrations of quercetin before and after hydrolysis using P-glucuronidase and sulfatase, respectively. The pharmacokinetic parameters were calculated using noncompartment model of WINNONLIN. The results showed that after intravenous administration of quercetin, 93.8% of the dose was circulating as its sulfates and glucuronides. After oral administration of quercetin, the glucuronides and sulfates of quercetin were exclusively present in the bloodstream, whereas the parent form of quercetin was not detected. The oral absorption rate of quercetin was 53% compared to intravenous administration after dose correction. When rutin was orally administered, sulfates and glucuronides of quercetin were exclusively present in the bloodstream, whereas rutin and quercetin were not detected. Quercetin showed higher oral absorption rate than rutin. In conclusion, quercetin sulfates and quercetin glucuronides represent the major metabolites either rutin or querectin was administered to rats. |
| 關聯: | JOURNAL OF FOOD AND DRUG ANALYSIS 13(3):239-243 |
| 顯示於類別: | [護理學系暨碩士班] 期刊論文
|
在CMUR中所有的資料項目都受到原著作權保護.
|
