Marked decrease of cyclosporin absorption caused by coadministration of Cordyceps sinensis in rats

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Title:	Marked decrease of cyclosporin absorption caused by coadministration of Cordyceps sinensis in rats
Authors:	Chiang, HM;Hou, YC;Tsai, SY;Yang, SY;Chao, PDL;Hsiu, SL;Wen, KC
Contributors:	藥學院藥妝系;China Med Univ, Sch Cosmeceut, Taichung, Taiwan;China Med Univ, Sch Pharm, Taichung, Taiwan;China Med Univ, Sch Chinese Med, Taichung, Taiwan;China Med Univ, Inst Pharmaceut Chem, Taichung, Taiwan;Jen Teh Jr Coll Med Nursing & Management, Miaoli, Taiwan
Date:	2005
Issue Date:	2010-09-24 18:53:19 (UTC+8)
Publisher:	NATL LABORATORIES FOODS DRUGS
Abstract:	Rutin and quercetin, a flavone glycoside and its aglycone, are the flavonoids most widely and abundantly present in herbs and plant foods. The aim of this study was to characterize and compare the bioavailability and metabolic pharmacokinetics of rutin and quercetin in rats. Quercetin was administered intravenously (33 mu mol/kg) and orally (165 mu mol/kg), while rutin was administered only orally (328 mu mol/kg) to rats. Blood samples were withdrawn via cardiopuncture at specific time points. An HPLC method was used to determine the concentrations of quercetin before and after hydrolysis using P-glucuronidase and sulfatase, respectively. The pharmacokinetic parameters were calculated using noncompartment model of WINNONLIN. The results showed that after intravenous administration of quercetin, 93.8% of the dose was circulating as its sulfates and glucuronides. After oral administration of quercetin, the glucuronides and sulfates of quercetin were exclusively present in the bloodstream, whereas the parent form of quercetin was not detected. The oral absorption rate of quercetin was 53% compared to intravenous administration after dose correction. When rutin was orally administered, sulfates and glucuronides of quercetin were exclusively present in the bloodstream, whereas rutin and quercetin were not detected. Quercetin showed higher oral absorption rate than rutin. In conclusion, quercetin sulfates and quercetin glucuronides represent the major metabolites either rutin or querectin was administered to rats.
Relation:	JOURNAL OF FOOD AND DRUG ANALYSIS 13(3):239-243
Appears in Collections:	[School and Institute of Nursing] Journal articles

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