Effects of platelet activating factor, butyrate and interleukin-6 on cyclooxygenase-2 expression in human esophageal cancer cells

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/30529

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题名:	Effects of platelet activating factor, butyrate and interleukin-6 on cyclooxygenase-2 expression in human esophageal cancer cells
作者:	Wang, LS;Chow, KC;Wu, YC
贡献者:	附設醫院醫研部;Taipei Vet Gen Hosp, Dept Surg, Div Thorac Surg, Taipei 112, Taiwan;China Med Coll Hosp, Dept Med Res, Taichung, Taiwan;Natl Yang Ming Univ, Taipei 112, Taiwan
日期:	2002
上传时间:	2010-09-24 14:57:07 (UTC+8)
出版者:	TAYLOR & FRANCIS AS
摘要:	Glycyrrhizin, a major component of Glycyrrhiza uralensis (licorice) root, is a saponin and exhibits a number of pharmacological effects, including anti-inflammation, anti-ulcer, anti-allergy, and anti-carcinogenesis. Activator protein 1 (AP-1), a nuclear transcription factor, consists of Jun/Fos heterodimers or Jun/Jun homodimers, and blocking of tumor promoter-induced AP-1 activity could inhibit induced cellular transformation. In order to elucidate the molecular mechanism of glycyrrhizin-induced antic arcinogenesis, effect of glycyrrhizin on the AP-1 activity in untreated and tumor promoter-12-O-tetradecanoylphorbol-13-acetate (TPA)-treated conditions was analyzed in this study. Glycyrrhizin induced the AP-1/TATA reporter activity in a dose-dependent fashion, which was judged by chloramphenicol acetyltransferase assay and electrophoretic mobility-shift assay. Similar results were observed in HepG2 and Vero cells, suggested that glycyrrhizin effect was cell type-independent. In addition, the cis element responsible for glycyrrhizin activity was AP-1 responsive element. Further analysis indicated that glycyrrhizin exhibited a different regulation on the AP-1 activity in untreated and TPA-treated cells. Glycyrrhizin induced the AP-1 activity in untreated cells, while it inhibited the TPA-induced AP-1 activation in TPA-treated cells. These results provide insight into the biological actions of glycyrrhizin and the molecular basis for the development of new chemoprotective agents for cancer. (C) 2002 Elsevier Science Inc. All rights reserved.
關聯:	SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY 37(4):467-475
显示于类别:	[台中附設醫院] 期刊論文

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