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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/29112
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| 題名: | Computer-aided diagnosis for surgical office-based breast ultrasound |
| 作者: | Chang, RF;Kuo, WJ;Chen, DR;Huang, YL;Lee, JH;Chou, YH |
| 貢獻者: | 附設醫院外科部;China Med Coll & Hosp, Dept Gen Surg, Taichung, Taiwan;Natl Chung Cheng Univ, Dept Comp Sci & Informat Engn, Chiayi, Taiwan;Vet Gen Hosp, Dept Radiol, Taipei, Taiwan |
| 日期: | 2000 |
| 上傳時間: | 2010-09-24 14:22:10 (UTC+8) |
| 出版者: | AMER MEDICAL ASSOC |
| 摘要: | Blackfoot disease (BFD) is a peripheral arterial occlusive disease found among human inhabitants along the southwest coast of Taiwan. Well water used for drinking and cooking contains humic acid (HA), which may be a possible etiological factor. In this study, HA toxicity was investigated in human erythrocytes and was found to induce echinocytic formation. Morphological changes occurred in both a concentration- and time-dependent fashion. The presence of HA was also observed to facilitate the loading of erythrocytes with excess Ca2+ (1 mM), which may have occurred following permeability changes in cell membranes, leading to echinocytic transformations. Sodium dodecyl sulfate (SDS) gel electrophoresis indicated that echinocyte formation was due to the oxidation of normal membrane proteins that were replaced by high-molecular-weight proteins. Humic acid also induced hemoglobin oxidation in erythrocytes. Data show that oxidative stress generated by HA as well as direct effects were exerted on the cytoskeleton of erythrocytes, and these may be significant factors in the etiology of BFD. |
| 關聯: | ARCHIVES OF SURGERY 135(6):696-699 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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