Computer-aided diagnosis for surgical office-based breast ultrasound

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Title:	Computer-aided diagnosis for surgical office-based breast ultrasound
Authors:	Chang, RF;Kuo, WJ;Chen, DR;Huang, YL;Lee, JH;Chou, YH
Contributors:	附設醫院外科部;China Med Coll & Hosp, Dept Gen Surg, Taichung, Taiwan;Natl Chung Cheng Univ, Dept Comp Sci & Informat Engn, Chiayi, Taiwan;Vet Gen Hosp, Dept Radiol, Taipei, Taiwan
Date:	2000
Issue Date:	2010-09-24 14:22:10 (UTC+8)
Publisher:	AMER MEDICAL ASSOC
Abstract:	Blackfoot disease (BFD) is a peripheral arterial occlusive disease found among human inhabitants along the southwest coast of Taiwan. Well water used for drinking and cooking contains humic acid (HA), which may be a possible etiological factor. In this study, HA toxicity was investigated in human erythrocytes and was found to induce echinocytic formation. Morphological changes occurred in both a concentration- and time-dependent fashion. The presence of HA was also observed to facilitate the loading of erythrocytes with excess Ca2+ (1 mM), which may have occurred following permeability changes in cell membranes, leading to echinocytic transformations. Sodium dodecyl sulfate (SDS) gel electrophoresis indicated that echinocyte formation was due to the oxidation of normal membrane proteins that were replaced by high-molecular-weight proteins. Humic acid also induced hemoglobin oxidation in erythrocytes. Data show that oxidative stress generated by HA as well as direct effects were exerted on the cytoskeleton of erythrocytes, and these may be significant factors in the etiology of BFD.
Relation:	ARCHIVES OF SURGERY 135(6):696-699
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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