CYL-418b Inhibited LPS Induced NO Production in Macrophage-Like Cell Lines.

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题名:	CYL-418b Inhibited LPS Induced NO Production in Macrophage-Like Cell Lines.
作者:	黃薰儀(Shun-Yi Huang);王繼平(Jip-Pyang Wang);許美鳳;林錦芬;李妙蓉*
贡献者:	醫學院醫學系學士班生化學科
日期:	2006-03-18
上传时间:	2009-09-07 10:40:30 (UTC+8)
摘要:	Inactivated macrophage, large amounts of nitric oxide (NO) are generated by inducible nitric oxide synthase (iNOS). This is an important mechanism in macrophage-induced cytotoxicity and inflammation. In this study, we examined the inhibitory effects of a synthetic compound CYL-418b, a derivative of 9-phenoxyacridine, on LPS induced inflammation. CYL-418b can effectively block lipopolysaccharide (LPS) induced NO production in murine macrophage (Raw 264.7) and microglial cell (BV-2) without obvious cytotoxcity. By focusing on the signaling pathway of NO production, CYL-418b did not reduce enzyme activity of iNOS. It inhibited LPS-induced iNOS expression at transcriptional steps. Our data indicated down regulation of NF-κB activity contributed to this inhibitory effect. Effects of CYL-418b on other pro-inflammatory cytokines production in Raw 264.7 and BV-2 stimulated by LPS will be further investigated.
關聯:	The 21th Joint Annual Conference of Biomedical Sciences
显示于类别:	[醫學系] 會議論文

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