中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/21021
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    CMUR > College of Medicine > School of Medicine > Proceedings >  Item 310903500/21021
    Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/21021


    Title: CYL-418b Inhibited LPS Induced NO Production in Macrophage-Like Cell Lines.
    Authors: 黃薰儀(Shun-Yi Huang);王繼平(Jip-Pyang Wang);許美鳳;林錦芬;李妙蓉*
    Contributors: 醫學院醫學系學士班生化學科
    Date: 2006-03-18
    Issue Date: 2009-09-07 10:40:30 (UTC+8)
    Abstract: Inactivated macrophage, large amounts of nitric oxide (NO) are generated by inducible nitric oxide synthase (iNOS). This is an important mechanism in macrophage-induced cytotoxicity and inflammation. In this study, we examined the inhibitory effects of a synthetic compound CYL-418b, a derivative of 9-phenoxyacridine, on LPS induced inflammation. CYL-418b can effectively block lipopolysaccharide (LPS) induced NO production in murine macrophage (Raw 264.7) and microglial cell (BV-2) without obvious cytotoxcity. By focusing on the signaling pathway of NO production, CYL-418b did not reduce enzyme activity of iNOS. It inhibited LPS-induced iNOS expression at transcriptional steps. Our data indicated down regulation of NF-κB activity contributed to this inhibitory effect. Effects of CYL-418b on other pro-inflammatory cytokines production in Raw 264.7 and BV-2 stimulated by LPS will be further investigated.
    Relation: The 21th Joint Annual Conference of Biomedical Sciences
    Appears in Collections:[School of Medicine] Proceedings

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