Lansoprazole is the proton pump inhibitor of a kind of benzimidazoles，It last coat of the stomach the cells not secreting uniqueness not all right ferment of hydrochloric acid in gastric juice (H + /K + the - ATPase) ，Make it activate，reduce the secretion of the hydrochloric acid in gastric juice。Apply to such various kinds of treatment resisting acid and secreting as the gastric ulcer、duodenal ulcer、adverse current esophagitis、Zollinger-Ellison disease groupetc。
Pellet can hit into the lozenge or pack into the capsule pharmaceutical， but the characteristic of the round one can overcome the time that the intestines and stomach shift difference，transformation in intestines and stomach to transport food influence of law，influence not emptied by the stomach either。The round one can be distributed evenly in the intestines and stomach，increase the area of absorbing in addition，improvement body availability on can big，can reduce between medicine and stimulus， intestines and stomach of mucous membrane.
Prepare Lansoprazole into the intestines to dissolve the destruction in
order to avoid the hydrochloric acid in gastric juice of round grains of form of a drug，use Wooster type flow bed is it prepare intestines dissolve round grain，is it design and act as content determining and relevant assessment with excipient so as to HPLC to fill a prescription to go on to utilize to come。Found by the experimental result，in the medicine floor， use Polyvinyl Alcohol (PVA) The best as binding the pharmaceutical result。 Because Lansoprazole easy to destroy PVA have stable result can prevent Lansoprazole from destroy among solution。In the casing floor， postpone medicines and justify one oneself to release with increase of the thickness of Eudragit® L30 D-55 different proportions。 When the thickness of floor of casing is too high，will influence and dissolve and leave the release that the speed suppresses the medicine。Make round grains of thing in addition，capsule thing assessment determine，including particle density，particle grain distribute directly，for a time content，water content of particle and dosage of unit。It is and then by body dissolve from testing,assess proportion thickness，the casings of layer not different dissolve to Lansoprazole from influence。Because the bag formed will postpone medicines to release to cover the thickness too thick，even prevent the medicine from releasing，but too thin to will release early too， make medicine destroy hydrochloric acid in gastric juice，can stimulate stomach too。
