Make use of special designs of different dosage form and controlled the dug release. Try the active ingredient Venlafaxine HCl by way of the bottom spray of the fluid bed machine and stick it on round one of sugar sphere. Different binders viz. PVP K-30, HPMC, HPC-SL were studied on the formulation design. The formulation was evaluated for different parameters such as drug loaded content and physical characteristic of the particle density, particle size distribution, moisture content. The surface of pellets was examined by scanning electron microscopy (SEM) and polarizing optical microscopy (POM) test.
Then core pellets were subsequently film-coated with ethylcellulose (Aquacote ECD-30) as controlled release polymer. The effect of drug to poly-
mer ratio on in vitro release was studied. In the medium of pH1.2, pH4.5,
pH6.8 of release profile were compared with marketed one of similar factor (F2) parameter.
The result shows with HPMC as binder was drug loaded the best formul-
lation. Dissolution test showed coating with 20% of ethylcellulose also get the desired extended-release.
