The intermediate compounds was synthesized by Baylis-Hillman reaction to couple acetaldehyde and the compound 13. We also used the starting compound 27 followed by reduction and Wittig rection to affored the intermediate compounds (E)-46, (Z)-46. The further works will be finished by Mitsunobu and Grubbs catalysis reaction to give to major compound 23.
A new method for synthesis of ??-2-deoxyglycosides from hex-1-en-3-uloses is reported, hex-1-en-3-uloses were shown to be efficient glycosyl donors by using catalyst amount of AlCl3 in microwave-assisted glycosylation. In these reaction ??-glycosyl additions occurred with highly stereoselectivity (??:??=10:1).
Fully protected endo-glucals are directly converted into compound 104, 105 by 1eq PhI(OH)OTs, followind addition amino in methanol at room temperature for 30 mins to affored the ??-enamino ketones.This sequestration reaction occurs in two steps which were studied separately and in a one-pot rection.
