Triterpene acids form the leaves of Planchonella duclitan (Blanco) Bakhuizan

CMUR > College of Pharmacy > School of Pharmacy/Master Degree Program, Ph. D program > Journal articles > Item 310903500/7693

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/7693

Title:	Triterpene acids form the leaves of Planchonella duclitan (Blanco) Bakhuizan
Authors:	(Lee, TH*);莊聲宏(Shin-Hun Juang);(Hsu, FL);(Wu CY)
Contributors:	藥學院藥學系;中國附醫醫學研究部細胞及基因治療研究室
Keywords:	Planchonella duclitan;Sapotaceae;Leaves;Triterpene acids;2α;3α;19α;23-tetrahydroxy-13;27-cyclours-Ⅱ-en-28-oic acid;HT29;MCF-7
Date:	2005-06
Issue Date:	2009-08-26 16:34:02 (UTC+8)
Abstract:	From the methanolic extract of the leaves of Planchonella duclitan, 2α, 3α, 19α, 23-tetrahydroxy-13, 27-cyclours-Ⅱ-en-28-oic acid (1), myrianthic acid (2), 2-hydroxyursolic acid (3), ursolic acid (4), pomolic acid (5), rotundic acid (6), and jacoumaric acid (7) were isolated, and their structures were elucidated on the basis of their spectroscopic analysis. Among them, compound 1 was a new cyclopropyl ursane-type triterpene acid. Additionally, compounds 4 and 7 showed significant cytotoxicity toward human colorectal carcinoma cell line HT29 and human breast carcinoma cell line MCF-7 with IC50 values ranging from 5.8±1.4 to 6.5±1.9μM.
Relation:	JOURNAL OF THE CHINESE CHEMICAL SOCIETY 52(6)1275 ~1280
Appears in Collections:	[School of Pharmacy/Master Degree Program, Ph. D program] Journal articles

Files in This Item:

File	Size	Format
	58Kb	Unknown	289	View/Open