Cytotoxicity of phenylpropanoid esters from the stems of Hibiscus taiwanensis

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Title:	Cytotoxicity of phenylpropanoid esters from the stems of Hibiscus taiwanensis Cytotoxicity of phenylpropanoid esters from the stems of Hibiscus taiwanensis
Authors:	吳培琳(Pei-Lin Wu);莊大賢(Ta-Hsien Chuang);賀彩霞(Cai-Xia He);吳天賞(Tian-Shung)*
Contributors:	藥學院藥學系
Keywords:	Malvaceae;Hibiscus taiwanensis;Lignan;9,9′-O-feruloyl-(−)-secoisolaricinresinol Malvaceae;Hibiscus taiwanensis;Lignan;9,9′-O-feruloyl-(−)-secoisolaricinresinol
Date:	2004-05 2004-05
Issue Date:	2009-08-26 16:32:08 (UTC+8) 2009-08-26 16:32:08 (UTC+8)
Abstract:	The separation of an extract prepared from the stems of the previously uninvestigated Hibiscus taiwanensis led to the isolation of three new phenylpropanoid esters, (7S,8S)-demethylcarolignan E (1), hibiscuwanin A (2), hibiscuwanin B (3), in addition to eight known ones. The structures of these compounds were elucidated by spectroscopic and chemical transformation studies. In cytotoxicity evaluation of the isolates, 9,9′-O-feruloyl-(−)-secoisolaricinresinol (8) showed strong cytotoxic activity against human lung carcinoma and breast carcinoma cell lines in an in vitro cytotoxicity assay with EC50 values of 1.8 and 3.9 μg/mL, respectively. Three new phenylpropanoid esters, (7S,8S)-demethylcarolignan E (1), hibiscuwanin A (2), hibiscuwanin B (3), in addition to eight known ones were isolated from the stems of Hibiscus taiwanensis. Among those isolates, 9,9′-O-feruloyl-(−)-secoisolaricinresinol (8) showed strong cytotoxic activity against human lung carcinoma and breast carcinoma cell lines with EC50 values of 1.8 and 3.9 μg/mL, respectively. The separation of an extract prepared from the stems of the previously uninvestigated Hibiscus taiwanensis led to the isolation of three new phenylpropanoid esters, (7S,8S)-demethylcarolignan E (1), hibiscuwanin A (2), hibiscuwanin B (3), in addition to eight known ones. The structures of these compounds were elucidated by spectroscopic and chemical transformation studies. In cytotoxicity evaluation of the isolates, 9,9′-O-feruloyl-(−)-secoisolaricinresinol (8) showed strong cytotoxic activity against human lung carcinoma and breast carcinoma cell lines in an in vitro cytotoxicity assay with EC50 values of 1.8 and 3.9 μg/mL, respectively. Three new phenylpropanoid esters, (7S,8S)-demethylcarolignan E (1), hibiscuwanin A (2), hibiscuwanin B (3), in addition to eight known ones were isolated from the stems of Hibiscus taiwanensis. Among those isolates, 9,9′-O-feruloyl-(−)-secoisolaricinresinol (8) showed strong cytotoxic activity against human lung carcinoma and breast carcinoma cell lines with EC50 values of 1.8 and 3.9 μg/mL, respectively.
Relation:	BIOORGANIC & MEDICINAL CHEMISTRY 12(9 )2193 ~2197 BIOORGANIC & MEDICINAL CHEMISTRY 12(9 )2193 ~2197
Appears in Collections:	[School of Pharmacy/Master Degree Program, Ph. D program] Journal articles

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