An Efficient and Convenient Method for Synthesis of 1-Substituted Imidazole

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Title:	An Efficient and Convenient Method for Synthesis of 1-Substituted Imidazole
Authors:	(Lin, C. M.;);翁豐富(Wong, Fung Fuh)*;(Yeh, M.-Y.)
Contributors:	藥學院藥物化學研究所
Keywords:	a-Bromo Ketone;1-Substituted Imidazole;1,3-Disubstituted Imidazolium Salt;Lithium Imidazolide
Date:	2006-07
Issue Date:	2009-08-26 16:27:51 (UTC+8)
Abstract:	A convenient method for the synthesis 1-substituted imidazoles was developed by the reaction of α-bromoketone with lithium imidazolide. The reaction gave the desired products in improved yields without the formation of 1,3-disubstituted imidazolium salts. Treatment of bromoacetaldehyde ethylene acetal, 2-(bromomethyl)tetrahydro-2H-pyran, and N-(bromomethyl)phthalimide with lithium imidazolide also gave the corresponding 1-substituted imidazole in good to excellent yields. Direct reaction of α-bromoketone with imidazole as control experiment afforded undesired 1,3-disubstituted imidazolium salts with the desired mono-substituted products.
Relation:	HETEROCYCLES 68(7 )1359 ~1370
Appears in Collections:	[Graduate Institute of Pharmaceutical Chemistry] Journal articles

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