Cytotoxic and Antimalarial beta-Carboline Alkaloids from the Roots of Eurycoma longifolia

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Title:	Cytotoxic and Antimalarial beta-Carboline Alkaloids from the Roots of Eurycoma longifolia
Authors:	(Ping-Chung Kuo);(Li-Shian Shi);(Amooru G. Damu);(Chung-Ren Su);(Chieh-Hung Huang);(Chih-Huang Ke);吳金濱;(Ai-Jeng Lin);(Kenneth F. Bastow);(Tian-Shung Wu)
Contributors:	藥學院藥物化學研究所
Date:	2003-06
Issue Date:	2009-08-26 16:26:32 (UTC+8)
Abstract:	Three new [n-pentyl beta-carboline-1-propinate(1), 5-hydroxymethyl-9-methoxycanthin-6-one(2), and 1-hydroxy-9-methoxycanthin-6-one(3), and 19 known beta-carboline alkaloids were isolated from the roots of Eurycoma longifolia. The new structures were determined bt comprehensive analyses of their 1D and 2D NMR and mass spectral data and by chemical transformation. These compounds were screened for in vitro cytotoxic and antimalarial activities, and 9-methoxycanthin-6-one (4) and canthin-6-one (5) demonstrated significant cytotoxicity against human cancer (A-549) and human breast cancer (MCF-7) cell lines.
Relation:	JOURNAL OF NATURAL PRODUCTS 66(10 )1324 ~1327
Appears in Collections:	[Graduate Institute of Pharmaceutical Chemistry] Journal articles

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