Synthesis of 1-Benzyl-3-(5-hydroxymethyl-2-furyl)indazole Analogues as Novel Antiplatelet Agents

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Title:	Synthesis of 1-Benzyl-3-(5-hydroxymethyl-2-furyl)indazole Analogues as Novel Antiplatelet Agents
Authors:	(F. Y. Lee);連金城;黃麗嬌(Li-Jiau Huang);(T. M. Huang);蔡勝忠;(C. M. Teng);(C. C. Wu);(F. C. Cheng);郭盛助(Sheng-Chu Kuo)*
Contributors:	藥學院藥物化學研究所
Date:	2001
Issue Date:	2009-08-26 16:26:10 (UTC+8)
Abstract:	1-Benzyl-3-(5’-hydroxymethyl-2’-furyl)indazole (28, YC-1) was selected as the lead compound for systemic structural modification. After screening for antiplatelet activity, SARs of YC-1 analogues were established. Among these potent active derivatives, compounds 29, 30, 31, 44, and 45 functioned as potent activators of sGC and inhibitors of PDE5 with potency comparable to that of YC-1. In addition, compound 58 was found to be a selective and potent inhibitor of protease-activated receptor type 4 (PAR4)-dependent platelet activation.
Relation:	JOURNAL OF MEDICINAL CHEMISTRY 44(22 )3746 ~3749
Appears in Collections:	[Graduate Institute of Pharmaceutical Chemistry] Journal articles

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