Analgesic and Anti-inflammatory Activities of the Aqueous Extract of Hydrocotyle batrachium Hance in Mice

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Title:	Analgesic and Anti-inflammatory Activities of the Aqueous Extract of Hydrocotyle batrachium Hance in Mice
Authors:	(Shyh-Shyun Huang);黃冠中(Huang Guan-jhong);彭文煌(Wen-Huang Peng);(Yu-Ling Ho);(Man-Jau Chang);(Hsin-Jung Hung);(Tien-Ning Chang);張永勳(Yuan Shiun Chang)*
Contributors:	藥學院中國藥學研究所;中國附醫藥劑部中藥局
Keywords:	抗發炎;福馬林;高效液相層析法;台灣天胡荽;扭體反應;λ- 角叉菜膠;ant-inflammation;formalin;high-performance liquid chromatography;Hydrocotyle batrachium Hance;writhing response;λ-carrageenan
Date:	2008
Issue Date:	2009-08-26 16:21:43 (UTC+8)
Abstract:	背景／目的　本研究探討台灣天胡荽水萃取物於小鼠之鎮痛及抗發炎作用。方法　研究台灣天胡荽水萃取物的鎮痛作用，以測量醋酸所誘導之扭體反應及福馬林注射後足蹠之舔足時間試驗進行。而λ-角叉菜膠(CARR)誘導足蹠浮腫試驗，可用於探討台灣天胡荽水萃取物之抗發炎作用。盧丁(rutin)、槲皮素(quercetin)及台彎天胡荽水萃取物之高效液相層析分析圖譜被建立。結果　以台灣天胡荽水萃取物100、500及1000mg/kg給藥的雄性ICR小鼠，對小鼠醋酸扭體反應次數產生了一個有意義且劑量依賴的抑制作用，而台灣天胡婪水萃取物在1000mg/kg濃度時，其抑制效果相同於吲哚美辛(indomethacin)在10mg/kg的抑制作用。台灣天胡荽水萃取物有意義的抑制福馬林所誘導的後期疼痛。台灣天胡荽水萃取物於500及1000mg/kg濃度下，也抑制了λ-角叉菜膠所誘導的足蹠浮腫現象二在高效液相層析分析中，我們則發現盧丁可能是台灣天胡荽水萃取物中的一個重要活性化合物。結論　台灣天胡荽水萃取物可能具有鎮痛及抗發炎活性。 Background/Purpose. To investigate the analgesic and anti-inflammatory effects of a water extract of Hydrocotyle batrachium Hance (HBW) in mice. Methods. The analgesic effects of HBW were investigated by measuring the acetic acid-induced writhing response and the hind paw licking time following formalin injection. λ-Carrageenan (CARR)-induced paw edema was studied to explore the anti-inflammatory effect of HBW. The chromatograms of rutin, quercetin and HBW were obtained by high-performance liquid chromatography (HPLC). Results. Treatment of male ICR mice with HBW (100, 500, 1000 mg/kg) inhibited the writhing response in a dose-dependent manner. The inhibitory effect of HBW at a dose of 1000 mg/kg was similar to that of indomethacin at a dose of 10 mg/kg. HBW significantly inhibited the degree of formalin-induced pain in the late phase. HBW (500, 1000 mg/kg) also inhibited the development of paw edema induced by CARR. The HPLC analysis revealed that rutin was an important bioactive compound in HBW. Conclusion. HBW appears to have analgesic and ant-inflammatory activities.
Relation:	Mid-Taiwan Journal of Medicine 13(4)179~185
Appears in Collections:	[Graduate Institute of Chinese Pharmaceutical Science] Journal articles

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