中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/7359
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    题名: Antioxidant and Antiproliferative Activities of Crossostephium chinensis (L.) Makino
    作者: (Tien-Ning Chang);黃冠中(Huang Guan-jhong);何玉鈴;(Shyh-Shyun Huang);(Heng-Yuan Chang);張永勳(Yuan Shiun Chang)*
    贡献者: 藥學院中國藥學研究所;中國附醫藥劑部中藥局
    关键词: Crossostephium chinensis;Antioxidant Activity;Superoxide;Total Phenols;Radical Scavenging;Antiproliferative;HepG2
    日期: 2009
    上传时间: 2009-08-26 16:21:15 (UTC+8)
    摘要: Crossostephium chinensis (L.) (CC) Makino is a common traditional Chinese medicinal plant used to dehumidify and cure rheumatism and arthralgia. The water and methanol extracts of C. chinensis (CCW and CCM) were evaluated for their antioxidant and antiproliferative activities. The antioxidant activities of CC were evaluated by using ABTS radical scavenging, DPPH radical scavenging, nitric oxide scavenging and superoxide scavenging methods. Iron chelating activity, lipid peroxidation, total polyphenol contents, total flavonoid contents and total flavonol contents were also detected. In all the tested models, both CCW and CCM showed their ability to scavenge the free radicals in a does-dependent manner. CCW had higher antioxidant and antiproliferative activities than CCM. In LC-MS-MS analysis, the chromatograms of CCW with good antioxidant activities were established. Rutin might be an important bioactive compound in CCW. The antiproliferative activities of CCW and CCM were also studied in vitro by using human hepatoma HepG2 cells. CCW exhibited good antiproliferative activity. These results indicated that CCW might be used as a potential source of natural antioxidants and as an anti-tumor agent.
    關聯: AMERICAN JOURNAL OF CHINESE MEDICINE 37(4) 1973~2010
    显示于类别:[中國藥學研究所(已停用)] 期刊論文

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