Effects of Gastrodia elata and its Active Constituents on Scopolamine-Induced Amnesia in Rats

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Title:	Effects of Gastrodia elata and its Active Constituents on Scopolamine-Induced Amnesia in Rats
Authors:	張永勳(Yuan Shiun Chang)
Contributors:	藥學院中國藥學研究所;中國附醫藥劑部中藥局
Keywords:	Gastrodiae elata;Orchidaceae;passive avoidance task;scopolamine;gastrodin;p-hydroxybenzyl alcohol
Date:	1996
Issue Date:	2009-08-26 16:21:04 (UTC+8)
Abstract:	The effects of the rhizome of Gastrodia elata Blume (Orchidaceae) (abbreviated as GE) and its active constituents on learning and memory by using the one-trial passive avoidance task were studied in rats. At the 1.0 g/kg dose administered for one week, the methanol extract of GE significantly prolonged the shortened step-through latency induced by scopolamine in the passive avoidance task. Furthermore, at the 50.0 mg/kg dose administered for one week, the ethyl acetate and n-butanol fractions of the methanol extract prolonged the shortened step-through latency induced by scopolamine in rats. Gastrodin, isolated from the n-butanol fraction of the methanol extract, and p-hydroxybenzyl alcohol, isolated from the ethyl acetate fraction of the methanol extract, also significantly prolonged the shortened step-through latency induced by scopolamine on the passive avoidance task. These results suggested that gastrodin and p-hydroxybenzyl alcohol may be the active constituents of GE.
Relation:	PLANTA MEDICA 62(4)317~321
Appears in Collections:	[Graduate Institute of Chinese Pharmaceutical Science] Journal articles

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