Analysis and Confirmation of Synthetic Anorexics in Adulterated Traditional Chinese Medicines by High Performance Capillary Electrophoresis

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Title:	Analysis and Confirmation of Synthetic Anorexics in Adulterated Traditional Chinese Medicines by High Performance Capillary Electrophoresis
Authors:	張永勳(Yuan Shiun Chang)
Contributors:	藥學院中國藥學研究所;中國附醫藥劑部中藥局
Keywords:	Amphetamine-like compounds
Date:	1999
Issue Date:	2009-08-26 16:20:50 (UTC+8)
Abstract:	Six synthetic anorexics, clobenzorex, diethylpropion, fenfluramine, methamphetamine, phenylpropanolamine and phentermine, which can be found as adulterants in traditional Chinese medicines were assayed simultaneously by high-performance capillary electrophoresis. The electrolyte was a buffer solution containing 120 mM phosphate buffer (NaH2PO4/H3PO4, pH 2.0) and 15% acetonitrile. Applied voltage was 16 kV and temperature was 30°C. Fluoren-2,7-diammonium chloride was used as an internal standard and detector set at 200 nm. The recoveries of the synthetic anorexic adulterants in traditional Chinese medicinal formula using C8-SCX mixed solid-phase extraction were studied. Several traditional Chinese medicinal powders obtained from clinics were also studied by the above HPCE method and confirmed by GC–MS. Clobenzorex, diethylpropion and fenfluramine were found and determined in these samples.
Relation:	JOURNAL OF CHROMATOGRAPHY A 848(2)537 ~543
Appears in Collections:	[中國藥學研究所(已停用)] 期刊論文

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