Dihydrobenzo[c]phenanthridine Alkaloids from Stem Bark of Zanthoxylum nitidum

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Title:	Dihydrobenzo[c]phenanthridine Alkaloids from Stem Bark of Zanthoxylum nitidum
Authors:	(Cheng-Hui Yang);(Ming-Jen Cheng);(Michael Y. Chiang);郭悅雄;(Chyi-Jia Wang);(Ih-Sheng Chen)*
Contributors:	藥學院中國藥學研究所;中國附醫院長室
Date:	2008
Issue Date:	2009-08-26 16:20:08 (UTC+8)
Abstract:	Five novel alkaloids, zanthomuurolanine (1), epi-zanthomuurolanine (2), zanthocadinanines A (3) and B (4), and epi-zanthocadinanine B (5), composed of dihydrochelerythrine and a cadinane-type sesquiterpene linked by a methylene bridge, have been isolated from stem bark of Zanthoxylum nitidum. These structures were elucidated by spectroscopic techniques (UV, IR, MS, CD, 1H NMR, 13C NMR, DEPT, COSY, NOESY, HSQC, and HMBC analyses). Single-crystal X-ray diffraction studies confirmed the relative configurations of 1 and 4 and provided additional support for the structures of 2, 3, and 5.
Relation:	JOURNAL OF NATURAL PRODUCTS 71(4)669~673
Appears in Collections:	[Graduate Institute of Chinese Pharmaceutical Science] Journal articles

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