Isolation and Identification of Novel Estrogenic Compounds in Yam Tuber ( Dioscorea alata cv. Tainung No 2 )

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题名:	Isolation and Identification of Novel Estrogenic Compounds in Yam Tuber ( Dioscorea alata cv. Tainung No 2 )
作者:	(Cheng, W. Y.);郭悅雄
贡献者:	藥學院中國藥學研究所;中國附醫院長室
关键词:	Discorea alata;phytoestrogen;chromanol;coenzyme Q9;1-feruloylglycerol;chromenol
日期:	2007-08
上传时间:	2009-08-26 16:19:45 (UTC+8)
摘要:	Yam (Dioscorea spp.) is a common food in tropical areas and has been shown to improve the status of sex hormone in postmenopausal women. In this study, the estrogenic activity of yam was examined and active compounds were isolated and identified based on ligand-dependent transcriptional activation through estrogen receptors. Ethyl acetate extracts of various species/varieties of yam were found to activate estrogen receptors α and β to various extents. The extract of Dioscorea alata cv. Tainung No. 2 tuber was fractionated by repeated silica gel column chromatography. The active compounds were isolated and purified by preparative HPLC. Based on NMR and mass spectrometry, two new compounds, hydro-Q9 chromene (1) and γ-tocopherol-9 (2), together with three known compounds, RRR-α-tocopherol (3), coenzyme Q9 (4), and 1-feruloylglycerol (5), were identified and shown to activate human ERα and β. These results provide basic evidence for the beneficial effect of yam for menopausal women.
關聯:	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 55(18 )7350~7358
显示于类别:	[中國藥學研究所(已停用)] 期刊論文

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