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    Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/7278


    Title: Hepatoprotective and antioxidant effects of ethanol extract from Phellinus merrillii on carbon tetrachloride-induced liver damage.
    Authors: 張恆源;彭文煌;許明志;黃冠中(Huang Guan-jhong);賴銘淙;何玉玲;曾金木;張永勳*
    Contributors: 藥學院中國藥學研究所
    Keywords: Phellinus merrillii;Carbon Tetrachloride;Hepatoprotective Effect;Antioxidant;High-Performance Liquid Chromatography
    Date: 2007-12
    Issue Date: 2009-08-26 16:18:34 (UTC+8)
    Abstract: In the present study, we investigated the hepatoprotective and antioxidant capacities of ethanol extract of Phellinus merrillii (PM) on carbon tetrachloride-induced hepatotoxicity. In high-performance liquid chromatography (HPLC) analysis, the finger print chromatogram of PM was established. Both hispolon and PM showed a similar peak at the retention time of 6 min. This implied that PM did contain the active ingredient of hispolon. Treatment with PM (0.5, 1 and 2 g/kg) prior to the administration of carbon tetrachloride (1.5 ml/kg in olive oil, 20%) significantly prevented the increased serum alanine aminotransferase (s-GOT) and serum aspartate aminotransferase (s-GPT) in a dose-dependent manner. We also found that the incidences of ballooning degeneration, necrosis and portal triaditis were lowered in the group pretreated with PM. Carbon tetrachloride induces up-regulation of antioxidant enzymes, including superoxide dismutase (SOD) (86.6%), catalase (58.8%) and glutathione peroxidase (GPx)(64.7%) in the liver. Pretreatment with PM significantly reduced the all these antioxidant enzyme activities. Therefore, we verified that ethanol extract of PM has the hepatoprotective and antioxidant capacities on rats.
    Relation: AMERICAN JOURNAL OF CHINESE MEDICINE 35(5)793~804
    Appears in Collections:[Graduate Institute of Chinese Pharmaceutical Science] Journal articles

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