目的 本研究探討益母草甲醇粗抽物對高膽固醇飲食誘導高脂血症大鼠降血脂之作用。方法 以高膽固醇飲食(2%膽固醇及1%膽酸)誘導產生高脂血大鼠，探討益母草甲醇粗抽物之降血脂作用及其機轉。結果 高膽固醇飲食每天口服餵食大鼠一次，連續14天可以誘導產生大鼠高脂血症，益母草甲醇粗抽物對高脂血症大鼠之血清總膽固醇、低密度脂蛋白膽固醇及肝臟之三酸甘油酯有明顯降低，且高密度脂蛋白膽固醇及脂蛋白脂酣顯著增加，血清極低密度脂蛋白膽固醇，肝臟之總膽固醇與糞便之總膽固醇及膽酸則無顯著影響。結論 益母草甲醇粗抽物可經由提高脂蛋白脂酶活性以加速血中脂質代謝及提高血清高密度脂蛋白濃度以加速血中膽固醇清除，達到降血脂作用。
Purpose. The present study investigated the hypolipidemic effect of methanol extract of Leonuri Herba (LH) on hyperlipidemic (HYP) rates fed a high cholesterol diet. Methods. Rats were fed a rich cholesterol diet (2% cholesterol and 1% bile acid) for two weeks to induce hyperlipidemia. To probe into the hypolipidemic mechanism of LH, the lipid levels in serum, liver and feces were measured on the 14th day. Results. The results showed that a high cholesterol diet induced hyperlipidemia in rats. LH reduced total cholesterol in serum, and LDL-C and triacylglycerol in the liver. In contrast, the HDL-C level and LPL activity increased. However, LH did not significantly affect VLDL-C level in the serum, TC level in the liver, or TC and BA levels in feces. Conclusions. LH produces a hypolipidemic effect by increasing LPL activity in serum, which causes an acceleration in blood lipid metabolism, and by removing blood cholesterol through an increase in HDL-C.
