The Ameliorating Effects of Cognition-enhancing Chinese Herbs on Scopolamine-and MK-801-induced Amnesia in Rats

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Title:	The Ameliorating Effects of Cognition-enhancing Chinese Herbs on Scopolamine-and MK-801-induced Amnesia in Rats
Authors:	(林穎志);吳啟瑞(Wu,Chi-Rei);(林君茹);謝明村(Hsieh,Ming-Tsuen)*
Contributors:	藥學院中國藥學研究所
Keywords:	Chinese herbs;passive avoidance task;scopolamine;MK-801
Date:	2003-12
Issue Date:	2009-08-26 16:17:04 (UTC+8)
Abstract:	The study was to investigate the ameliorating effects of three Chinese herbs — Achyranthes bidentata (AB), Ophiopogon japonicus (OJ) and Cnidium monnieri (CM) on scopolamine (SCOP)- and MK-801-induced amnesia by using a passive avoidance task in rats. AB, OJ and CM at 0.1 and 0.3 g/kg prolonged the step-through latency (STL) of the retention trial. In addition, AB, OJ and CM reversed the STL shortened by MK-801, but only AB reversed the STL shortened by SCOP. In conclusion, these Chinese herbs possess cognition-enhancing activities and anti-amnestic effects, but the mechanism of the effect of AB was different from those of OJ and CM.
Relation:	AMERICAN JOURNAL OF CHINESE MEDICINE 31(4)543 ~549
Appears in Collections:	[Graduate Institute of Chinese Pharmaceutical Science] Journal articles

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