Hyperintense Putaminal Rim Sign Is Not a Hallmark of Multiple System Atrophy at 3T

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Title:	Hyperintense Putaminal Rim Sign Is Not a Hallmark of Multiple System Atrophy at 3T
Authors:	(Wei-Hsing Lee);(Chau-Chin Lee);徐偉成;(Pau-Nyen Chong);林欣榮(Shinn-Zong Lin)
Contributors:	醫學院臨床醫學研究所;中國附醫神經部
Date:	2005-10
Issue Date:	2009-08-26 16:13:24 (UTC+8)
Abstract:	BACKGROUND AND PURPOSE: Hyperintense putaminal rim (HPR) on the T2-weighted imaging, which has been observed in our daily practice while reading 3T brain images, has been described as a finding typical of multiple system atrophy (MSA). We hypothesized that the HPR sign is not an exclusive hallmark of MSA at a high magnetic field strength, but rather may be a normal finding. METHODS: Ten consecutive clinically healthy age-matched adults who showed recognizable HPR at 3T were subsequently examined on a 1.5T imaging system within 2 hours. MR examination included axial T2-weighted fast spin-echo (FSE), fluid attenuated inversion recovery (FLAIR) on a 3T scanner, and equivalent T2-weighted FSE at 1.5T. MR images were obtained parallel to the intercommissural plane. All the images were interpreted by 2 experienced neuroradiologists. RESULTS: All 10 subjects (3 men and 7 women; aged 52 ± 6.1 years [range, 44–61 years], expressed as mean ± SD) with the positive HPR sign on axial T2-weighted FSE at 3T had negative findings at 1.5T. Such hyperintense rim was also vague or absent on the 3T-FLAIR images. CONCLUSION: Our data suggest that the HPR at 3T scans is a nonspecific, normal finding. FLAIR may be helpful in discriminating between normal subjects and patients with MSA in case of isolated HPR at 3T.
Relation:	AMERICAN JOURNAL OF NEURORADIOLOGY 26(0)2238 ~2242
Appears in Collections:	[Graduate Institute of Clinical Medical Science] Journal articles

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