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    題名: EBNA1 may prolong G2/M phase and sensitize HER2/neu-overexpressing ovarian cancer cells to both topoisomerase II-targeting and paclitaxel drugs
    作者: (Chuang TC);(Lee YJ);(Liu JY);(Lin YS);(Lee JW);(Wang V);(Law SL);高銘欽(Ming-Ching Kao)*
    貢獻者: 醫學院臨床醫學研究所
    關鍵詞: HER2/neu;EBNA1;Tumorigenicity;Ovarian cancer
    日期: 2003-08
    上傳時間: 2009-08-26 16:12:43 (UTC+8)
    摘要: We have shown previously that the Epstein-Barr virus nuclear antigen-1 (EBNA1) can act as a transforming suppressor in the HER2/neu-overexpressing ovarian cancer cells. In the present study, by using flow cytometric analysis, we demonstrate that EBNA1 could prolong G(2)/M phase and sensitize to Taxol-induced apoptosis in the EBNA1-expressing ovarian cancer cell stable transfectants. In addition, EBNA1 could also significantly increase topoisomerase IIalpha protein expression, indicating that the up-regulation of topoisomerase IIalpha may be one of the mechanisms by which EBNA1 enhances the sensitivity of ovarian cancer cells to topoisomerase II-targeting anticancer drugs, such as VP-16 and Adriamycin. These data suggest that EBNA1 not only prolongs cell cycle at G(2)/M phase and up-regulates topoisomerase IIalpha expression in HER2/neu-overexpressing ovarian cancer cells, but also increases cellular apoptosis through sensitization of cancer cells to topoisomerase II-directing anticancer drugs.
    關聯: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 307(3)653~659
    顯示於類別:[臨床醫學研究所] 期刊論文

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