B2-Microglobulin Is a Signaling and Growth-Promoting Factor for Human Prostate Cancer Bone Metastasis

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 醫學院 > 癌症生物學研究所 > 期刊論文 > Item 310903500/7058

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題名:	B2-Microglobulin Is a Signaling and Growth-Promoting Factor for Human Prostate Cancer Bone Metastasis
作者:	(Wen-Chin Huang);(Daqing Wu);(Zhihui Xie);(Haiyen E. Zhau);(Takeo Nomura);(Jan Pohl);謝嘉玲;(M. Neale Weitzmann);(Mary C. Farach-Carson);(Leland W.K. Chung)*
貢獻者:	醫學院癌症生物學研究所;中國附醫分子醫學中心腫瘤基因
關鍵詞:	β2-microglobulin;caspases and apoptosis;cAMP-responsive element binding protein;cyclins and cellcycle;osteomimicry;siRNA and targeting
日期:	2006-09
上傳時間:	2009-08-26 16:10:57 (UTC+8)
摘要:	The protein factor β2-microglobulin (β2M), purified from the conditioned medium of human prostate cancer cell lines, stimulated growth and enhanced osteocalcin (OC) and bone sialoprotein (BSP) gene expression in human prostate cancer cells by activating a cyclic AMP (cAMP)–dependent protein kinase A signaling pathway. When β2M was overexpressed in prostate cancer cells, it induced explosive tumor growth in mouse bone through increased phosphorylated cAMP-responsive element binding protein (CREB) and activated CREB target gene expression, including OC, BSP, cyclin A, cyclin D1, and vascular endothelial growth factor. Interrupting the β2M downstream signaling pathway by injection of the β2M small interfering RNA liposome complex produced an effective regression of previously established prostate tumors in mouse bone through increased apoptosis as shown by immunohistochemistry and activation of caspase-9, caspase-3, and cleavage of poly(ADP-ribose) polymerase. These results suggest that β2M signaling is an attractive new therapeutic target for the treatment of lethal prostate cancer bone metastasis.
關聯:	CANCER RESEARCH 66(18 )9108 ~9116
顯示於類別:	[癌症生物學研究所] 期刊論文

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