Overexpression of protein kinase Cα mRNA in human hepatocellular carcinoma: a potential marker of disease prognosis

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Title:	Overexpression of protein kinase Cα mRNA in human hepatocellular carcinoma: a potential marker of disease prognosis
Authors:	(Trang-Tiau Wu);(Yi-Hsien Hsieh);(Cheng-Chung Wu);(Yih-Shou Hsieh);黃志揚(Chih-Yang Huang);劉哲育(Liu Jer-Yuh)*
Contributors:	醫學院癌症生物學研究所;中國附醫分子醫學中心-分子內分泌學
Keywords:	Protein kinase Cα;Hepatocellular carcinoma
Date:	2007-07
Issue Date:	2009-08-26 16:10:47 (UTC+8)
Abstract:	Abstract Members of the protein kinase C (PKC) isoenzyme family play a central role in the tumorigenesis of several tissues. However, little is known about subtype specific intracellular expression of PKC in human hepatocellular carcinomas. Methods We investigated PKC isoforms mRNA expression in 42 HCC specimens using reverse transcription polymerase chain reaction analysis, and the correlation between PKC isoforms expression and clinicopathologic parameters. Results We found that PKCα, PKCδ and PKCι mRNA were significantly increased in HCCs as compared to the corresponding non-cancerous liver tissues. PKCα expression also significantly correlated with tumor size (P < 0.05) and TNM stage (P < 0.05), but PKCδ and PKCι did not. The log-rank analysis revealed that patients with higher PKCα mRNA expression in the HCC tissues had significantly shorter survival rate than patients with lower PKCα mRNA expression (P < 0.01). Conclusions Our results suggested that the PKCα may be a prognostic factor for the survival of patients with HCC.
Relation:	CLINICA CHIMICA ACTA 382(1-2 )54 ~58
Appears in Collections:	[Graduate Institute of Cancer Biology] Journal articles

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