以健檢正子造影檢視年齡與性別對腦內葡萄糖代謝之影響; Age and Gender Influences 18F-deoxyglucose (FDG) metabolism in normal Healthy Examination Study --A PET study

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题名:	以健檢正子造影檢視年齡與性別對腦內葡萄糖代謝之影響;Age and Gender Influences 18F-deoxyglucose (FDG) metabolism in normal Healthy Examination Study --A PET study
作者:	魏銘政;Ming-Cheng Wei
贡献者:	中國醫藥大學：臨床醫學研究所碩士班
关键词:	正子造影;年齡;性別;統計參數定位;PET;age;sex;SPM
日期:	2006-07-25
上传时间:	2009-08-12 14:23:36 (UTC+8)
摘要:	在過去我們要作腦部半定量分析時，常常需要人工手動圈選感興趣區(ROI, region of interest)，然後測量其計數值。之後使用統計軟體處理實驗數據，例如SAS、SPSS、或使用Microsoft Excel做資料統計，比較差異性。但是常常因不同人圈選之位置、大小不同，極易造成人為誤差，以及只能得到資料數據上的變化，比較沒有整體性(Hall et al., 1991; Hibbard et al., 1987; Zhao et al., 1995, 1996)，因此SPM軟體便孕育而生。在以SPECT / PET 及 fMRI 等功能性腦造影儀器,獲取大腦影像空間訊息的統計及資料分析的軟體中，SPM（Statistical Parametric Mapping , Friston 1991 ,The Wellcome Department of Imaging Neuroscience 的 Functional Imaging Laboratory）是最為全世界的認知神經科學家在科學期刊中被引用次數最多的一套分析軟體(http://www.fil.ion.ucl.ac.uk/spm/)。 SPM (Friston et al., 1991,1994; Poline et al., 1995; Worsley et al., 1992),是結合受試者影像和統計方法的軟體，是把影像體素(Voxel)和體素之間差異值的統計比較，一般可以應用於核醫造影PET/SPECT或是磁振功能造影(fMRI)腦神經功能研究。在過去的論文經驗之中,我們看到了利用腦部功能性核磁共振(fMRI),單光子放射電腦斷層掃描(SPECT)來檢視腦部局部血流量藉以探討不同腦部區域所代表的功能定位(brain mapping) 葡萄糖是腦部代謝最重要的物質.正子斷層掃描(PET)是利用帶有放射線的葡萄糖,藉由其在腦部的吸收狀況,用以代表其局部區域的代謝功能.藉以認定其所代表的功能性定位。我們由中國醫藥大學附設醫院,接受健檢正子造影的正常人之中,排除了有全身性系統疾病的病人之後。將其分為男性小於60歲,男性大於60歲,女性小於60歲,以及女性大於60歲共四組,各25人,作交叉比對。分析其腦部代謝是否有基本上的差異。在經過排除有系統性疾病的病人之後,進行正子造影.再來我們利用SPM軟體先將受試者的影像資料作前處理的動作，如重新定位，均勻化所有影像，並使所有影像平滑化。之後選擇我們要統計的方式，作Two-sample T-Test模式，選擇此實驗目的主題之受試者影像，設定P值<0.05為有統計學意義。當有差異的部分(實驗P值小於設定值時)出現時,則會顯示在Talairach space解剖座標圖上(黑點區塊)，我們就可以知道在腦部區域出了什麼問題。由結果可以看出, 綜合以上的研究結果結論出，健康成人的腦部葡萄糖代謝,在不同性別及年齡有基本上的不同。就男性而言,年輕男性在理解力(BA24)及情緒反應(BA47)較為激烈。就女性而言,年輕女性在情緒反應(BA38,47)較為激烈。而年輕男性較年輕女性於視覺動作（BA19）及記憶語言(BA37)有較佳表現。　 In the passes, when we make the brain semi-quantity analysis, We frequently needs to circle the interest area (ROI, region of interest), then surveys it to count the value. Then uses the statistical software processing empirical datum afterwards, for example SAS, SPSS, or use Microsoft Excel to make the material statistics, compared with difference. But frequently because of the different person circle the different position and size , is extremely easy to create the personal error, as well as only can obtain the change in the material data, compared with does not have the integrity (Hall et al., 1991; Hibbard et al., 1987; Zhaoet al., 1995, 1996).Therefore the SPM software then breeds lives. In functional brain image instrument and so on SPECT/PET and fMRI, to gains the cerebrum space image and the material analysis software, SPM (Statistical Parametric Mapping, Friston 1991, The Wellcome Department of Imaging Neuroscience Functional Imaging Laboratory) is the most world cognition department of neurology scientist is quoted a number of times most set of analyses software in the scientific periodical (http://www.fil.ion.ucl.ac.uk/spm/). SPM (Friston et al., 1991,1994 ; Poline et al., 1995; Worsley et al., 1992), is the union the trying image and the statistical method software. It is comparison the difference statistical value in the image between the voxel and voxel, It generally may be supposed to use in nuclear medical radiography PET/SPECT perhaps the function radiography (fMRI) the brain function research. During the past paper experience, we saw the use of brain function nuclear magnetic resonance (fMRI), the single photon emission computer scan (SPECT) .It inspect the regional brain blood current capacity so as to discuss the functional localization which the different brain region represents (brain mapping) We set up cases who accept the PET (Positron Emission Tomography) in healthy exam in the hospital by the Chinese medicine university, after excluded the patient which has the whole body system disease. Divides cases into the male it to be smaller than 60 years old, the male is bigger than 60 years old, the female is smaller than 60 years old, as well as the female is bigger than 60 years old of altogether four groups, each 25 people, processing intersect analyzes of his/her brain metabolism whether has basic difference. Glucose is the most important material in brain metabolism .The Positron Emission Tomography (PET) use has the radioactive glucose, the affiliation by it in the brain absorption condition, with represents its partial region metabolism function .So as to recognized its functional localization. After excluded the patient which has the systematic disease, carries on the Positron Emission Tomography .Then use the SPM software pre-process of image material as segmentation ,normalization and smoothing. Chooses the way afterwards which we must count, makes Two-sample the T-Test pattern, chooses this experimental goal subject in the trying image, establishes the P value to be smaller than 0.05 as statistics result . Then demonstrate in Talairach space (dark spot), We may know had any problem in the brain region. May see by the result, above the synthesis findings conclusion leaves, the healthy adult''s brain glucose metabolism, has basic different in the sex and the age. Speaking of the male, the young male is intense in the comprehension faculty (BA24) and the mood response (BA47). Speaking of the female, the young female is intense in the mood response (BA38,47). But a young male has a better performance to the visual movement (BA19) and the memory, language (BA37) then younger female.
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