Structural basis of a flavivirus recognized by its neutralizing antibody: solution structure of the domain III of the Japanese encephalitis virus envelope protein.

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 醫學院 > 醫學檢驗生物技術學系暨碩士班 > 期刊論文 > Item 310903500/6781

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题名:	Structural basis of a flavivirus recognized by its neutralizing antibody: solution structure of the domain III of the Japanese encephalitis virus envelope protein.
作者:	(Wu KP);(Wu CW);(Tsao YP);(Kuo TW);(Lou YC);林振文(Cheng-Wen Lin);(Wu SC);(Cheng JW)
贡献者:	健康照護學院醫學檢驗生物技術學系;中國附醫檢驗醫學部
日期:	2003-11
上传时间:	2009-08-26 16:00:25 (UTC+8)
摘要:	The flavivirus envelope protein is the dominant antigen in eliciting neutralizing antibodies and plays an important role in inducing immunologic responses in the infected host. We have determined the solution structure of the major antigenic domain (domain III) of the Japanese encephalitis virus (JEV) envelope protein. The JEV domain III forms a β-barrel type structure composed of six antiparallel β-strands resembling the immunoglobulin constant domain. We have also identified epitopes of the JEV domain III to its neutralizing antibody by chemical shift perturbation measurements. Site-directed mutagenesis experiments are performed to confirm the NMR results. Our study provides a structural basis for understanding the mechanism of immunologic protection and for rational design of vaccines effective against flaviviruses.
關聯:	JOURNAL OF BIOLOGICAL CHEMISTRY 278(46)46007~46013
显示于类别:	[醫學檢驗生物技術學系暨碩士班 ] 期刊論文

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