Epigenetic changes of tumor suppressor genes, P15, P16, VHL and P53 in oral cancer.

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 醫學院 > 醫學檢驗生物技術學系暨碩士班 > 期刊論文 > Item 310903500/6746

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題名:	Epigenetic changes of tumor suppressor genes, P15, P16, VHL and P53 in oral cancer.
作者:	葉坤土(Yeh KT);張建國(Chang JG);(Lin TH);(Wang YF);田霓;(Chang JY);(Chen JC);施木青(Mu-Chin Shih)
貢獻者:	健康照護學院醫學檢驗生物技術學系
日期:	2003.05
上傳時間:	2009-08-26 15:59:53 (UTC+8)
摘要:	We performed methylation specific PCR to explore the mechanism of inactivation of tumor suppressor genes P15, P16, P53 and VHL in 48 oral SCC. The frequencies of aberrant methylation on the promoter of the P15, the P16, the P53 and the VHL genes were 0.27 (13/48), 0.42 (20/48), 0.04 (2/48) and none, respectively. Altogether, over 50% of the samples showed the CpG-island methylation modification in at least one of the three tumor suppressor genes, indicating that the frequent inactivation of these genes may be an important step during oral cancer development, and the methylation inactivation of P15 or P16 may occur at pre-cancerous stage.
關聯:	CHINESE CHEMICAL LETTERS 10(3 )659 ~663
顯示於類別:	[醫學檢驗生物技術學系暨碩士班 ] 期刊論文

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