G-33A mutation in the promoter region of thrombomodulin gene and its association with coronary artery disease and plasma soluble thrombomodulin levels

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Title:	G-33A mutation in the promoter region of thrombomodulin gene and its association with coronary artery disease and plasma soluble thrombomodulin levels
Authors:	(Li YH);(Chen JH);(Wu HL);(Shi GY);黃蕙君(HUANG, Huey-Chun);(Chao TH);(Tsai WC);(Tsai LM);(Guo HR);(Chen ZC)
Contributors:	健康照護學院醫學檢驗生物技術學系
Date:	2000.01
Issue Date:	2009-08-26 15:59:51 (UTC+8)
Abstract:	Thrombomodulin is an endothelial glycoprotein that decreases thrombin activity and activates protein C. A recent study has shown that G-33A promoter mutation of the thrombomodulin gene occurs particularly in Asians. In this study, we analyzed the distribution of G-33A mutation in the promoter region of the thrombomodulin gene in the Chinese population and determined whether the mutation might be a risk for coronary artery disease (CAD). In addition, the influence of this mutation on plasma soluble thrombomodulin levels in patients with CAD was also examined. We studied 320 consecutive patients (mean age 63 years; 73% men) with CAD and 200 age- and sex-matched control subjects. Screening for thrombomodulin G-33A promoter mutation was conducted using polymerase chain reaction, single-strand conformation polymorphism, and direct deoxyribonucleic acid sequencing. The frequency of the G-33A mutation (GA+AA genotypes) was significantly higher in the CAD group (23.8% vs 15.5%, odds ratio [OR] 1.70, p = 0.031). Multiple logistic regression analysis showed that the mutation was an independent risk factor (OR 1.81, p = 0.016) for CAD, as was hypertension (OR 1.44, p = 0.040), diabetes mellitus (OR 2.50, p
Relation:	AMERICAN JOURNAL OF CARDIOLOGY 85(1 )8 ~12
Appears in Collections:	[Department of Medical Laboratory Science and Biotechnology ] Journal articles

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