Human Rh Del is caused by a deletion of 1013 bp between introns 8 and 9 including exon 9 of Rh D gens

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 醫學院 > 醫學檢驗生物技術學系暨碩士班 > 期刊論文 > Item 310903500/6741

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题名:	Human Rh Del is caused by a deletion of 1013 bp between introns 8 and 9 including exon 9 of Rh D gens
作者:	張建國(Chang JG);(Wang JC);(Yang TY);(Tsan KW);施木青(Mu-Chin Shih);彭慶添(Ching-Tien Peng);蔡長海(Chang-Hai Tsai)
贡献者:	健康照護學院醫學檢驗生物技術學系
日期:	1998.10
上传时间:	2009-08-26 15:59:47 (UTC+8)
摘要:	The Rh system is genetically controlled by two different but highly homologous genes on chromosome 1p34-36. The RHCE gene encodes a different RhCcEe polypeptide and the RHD gene encodes the D polypeptide, and there are a large number of antigenic polymorphisms between these two peptides. Of these, the RhDel is characterized as RhD by using a conventional serological test, but it does show absorption and elution of anti-D.1 The molecular basis of RhDel is not known. The blood of 21 Del (21.6%) of 102 serological RHD patients was obtained after an absorption and elution test. A modified polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method based on the polymorphisms between RHCE and RHD genes was used to analyze the Del gene structure,2 and the results showed that there was no difference between the RhD and RhDel gene except that at the BspHI site of exon 9, the Del gene lacked the BspHI site that was similar with the RHCE gene. Haplotyping by Sph I bands showed no gross difference between RHD and RHDel genes3 (data not shown).
關聯:	ARCHIVES ITALIENNES DE BIOLOGIE 92(7)2602~2604
显示于类别:	[醫學檢驗生物技術學系暨碩士班 ] 期刊論文

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