Salvianolic Acid B Modulates Hemostasis Properties of Human Umbilical Vein Endothelial Cells

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 醫學院 > 醫學檢驗生物技術學系暨碩士班 > 期刊論文 > Item 310903500/6738

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题名:	Salvianolic Acid B Modulates Hemostasis Properties of Human Umbilical Vein Endothelial Cells
作者:	(Chung-Sheng Shi);黃蕙君;(Hua-Lin Wu);(Cheng-Hsiang Kuo);(Bi-Ing Chang);(Ming-shi Shiao);(Guey-Yueh Shi)
贡献者:	健康照護學院醫學檢驗生物技術學系
日期:	2007.01
上传时间:	2009-08-26 15:59:45 (UTC+8)
摘要:	Salviae Miltiorrhizae (SM), a clinically common used herb, can activate blood circulation and resolve stasis. We have investigated the effects of salvianolic acid B (Sal B), a pure compound extracted from the dried SM roots, on fibrinolytic (tissue-type plasminogen activator and plasminogen activator inhibitor, t-PA and PAI) and anticoagulant (thrombomodulin,TM) properties of cultured human umbilical vein endothelial cells (HUVECs). When HUVECs were treated with Sal B, a dose (0.0125-0.5 mg/ml) and a time-dependent decrease in PAI activity were observed. PAI type 1 (PAI-1) antigen and PAI-1 mRNA expression significantly decreased compared to control values in the conditioned media of HUVECs pretreated with Sal B for 12 h. Moreover, TM activity reached a maximum stimulation of 1.25 fold over control levels in the pretreatment of Sal B for 12 h and t-PA and TM specific mRNA expression also increased (1.7 and 1.8 fold, respectively). In conclusion that Sal B increased the fibrinolytic and anticoagulant potential of cultured HUVECs by up-regulating the expression of t-PA and TM, and by down-regulating the expression of PAI-1. These data suggest that Sal B is clinically effective because of its ability to change the gene expression profile of endothelial cells thereby preventing vascular events.
關聯:	THROMBOSIS RESEARCH 6(119 )769 ~775
显示于类别:	[醫學檢驗生物技術學系暨碩士班 ] 期刊論文

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