Mutation analysis of the putative tumor suppression gene PTEN/MMAC1 in sporadic breast cancer

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 醫學院 > 醫學檢驗生物技術學系暨碩士班 > 期刊論文 > Item 310903500/6737

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题名:	Mutation analysis of the putative tumor suppression gene PTEN/MMAC1 in sporadic breast cancer
作者:	(Chen ST);(Yu SY);(Tsai M);葉坤土(Yeh KT);(Wang JC);(Kao MC);施木青(Mu-Chin Shih);張建國(Chang JG)
贡献者:	健康照護學院醫學檢驗生物技術學系
日期:	1999.05
上传时间:	2009-08-26 15:59:44 (UTC+8)
摘要:	PTEN/MMAC1, a potential human tumor suppressor gene, has been found to have inactivating mutations in several types of cancer, including breast cancer. The incidence of breast cancer in Chinese is quite low in comparison with Caucasians, and genetic factors may play some roles. To further determine the role of PTEN/MMAC1 in breast cancer in Chinese, we used loss of heterozygosity (LOH), single strand conformation polymorphism (SSCP) with direct sequencing of variant bands, and Southern blot analysis methods to analyze mutations in PTEN/MMAC1 in 52 cases of breast cancer. None had LOH at chromosome 10q23.3. One mutation was identified, a somatic 3-base deletion, in one case. Our results suggest PTEN/MMAC1 does not play a major role in the development of sporadic breast cancer.
關聯:	JOURNAL OF FUSION ENERGY 55(1 )85 ~89
显示于类别:	[醫學檢驗生物技術學系暨碩士班 ] 期刊論文

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