Meticillin-resistant Staphylococcus aureus infection in diabetic mice enhanced inflammation and coagulation

CMUR > College of Health Care > Graduate Institute of Nutrition > Journal articles > Item 310903500/6677

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/6677

Title:	Meticillin-resistant Staphylococcus aureus infection in diabetic mice enhanced inflammation and coagulation
Authors:	殷梅津(YIN, MEI-CHIN)*
Contributors:	健康照護學院營養學系
Date:	2006-07
Issue Date:	2009-08-26 15:57:29 (UTC+8)
Abstract:	BALB/cA mice were used to study the interaction of diabetes and meticillin-resistant Staphylococcus aureus (MRSA) infection on pathogen distribution, cytokine profile and inflammatory and endothelial-injury markers, as well as coagulation and anticoagulation factors. Meticillin-susceptible S. aureus (MSSA) infection did not cause death within the experimental period. MRSA-infected nondiabetic and diabetic mice died on 19·1±1·4 and 10·6±0·7 days post-infection (p.i.), respectively. MRSA and MSSA infection in diabetic mice did not result in symptomatic bacteraemia; however, MRSA infection in diabetic mice significantly reduced glucose levels (P<0·05). Diabetic mice showed significantly higher levels of C-reactive protein, fibrinogen, fibronectin and von Willebrand factor than nondiabetic mice (P<0·05), and MRSA infection further elevated the plasma levels of these inflammatory and endothelial markers (P<0·05). Before infection, diabetic mice had significantly higher plasminogen activator inhibitor-1 (PAI-1) activity, lower antithrombin III (AT-III) and protein C activities (P<0·05), and MRSA infection significantly increased PAI-1 activity further and reduced the activity of AT-III and protein C (P<0·05). MRSA infection increased the production of three Th1 cytokines, interleukin 2 (IL-2), tumour necrosis factor alpha and gamma interferon, in diabetic mice (P<0·05); however, three Th2 cytokines, IL-4, IL-6, IL-10, were elevated at 2 and 4 days p.i., and then dropped gradually. MRSA infection in diabetic mice accelerated the inflammation process, endothelial injury and blood coagulation in diabetic mice. Therefore, the development of proper infection diagnosis and timely use of effective treatments for MRSA-infected diabetic individuals is important and necessary.
Relation:	JOURNAL OF MEDICAL MICROBIOLOGY 55(2006)379 ~385
Appears in Collections:	[Graduate Institute of Nutrition ] Journal articles

Files in This Item:

File	Size	Format
	58Kb	Unknown	215	View/Open

Loading...