Altitude Hypoxia Increases Glucose Uptake in Human Heart

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Title:	Altitude Hypoxia Increases Glucose Uptake in Human Heart
Authors:	(Chi-Hsien Chen);(Yeh-Feng Liu);李信達(Shin-Da Lee);(Wen-Chih Lee);(Ying-Lan Tsai);(Chien-Wen Hou);黃志揚(Chih-Yang Huang);(Chia-Hua Kuo)*
Contributors:	健康照護學院物理治療學系
Date:	2009-03
Issue Date:	2009-08-26 15:55:23 (UTC+8)
Abstract:	Chen, Chi-Hsien, Yuh-Feng Liu, Shin-Da Lee, Wen-Chih Lee, Ying-Lan Tsai, Chien-Wen Hou, Chih-Yang Huang, and Chia-Hua Kuo. Altitude hypoxia increases glucose uptake in human heart. High Alt. Med Biol. 10:83–86, 2009.—Cardiac muscle is a highly oxygenated tissue that produces ATP mainly from fat oxidation. However, when the rate of oxygen demand exceeds oxygen supply, energy reliance on the carbohydrate substrate becomes crucial for sustaining normal cardiac function. In this study, the effect of acute altitude hypoxia on glucose uptake from circulation was determined, for the first time, in the human heart, using [18F]-2-deoxy-2-fluoro-D-glucose positron emission tomography (FDG-PET) in a simulated altitude condition (14% O2, corresponding to 3000 m above sea level) or room air (21% O2). Our results showed that subjects (n = 6) started to experience difficulty in sustaining the hypoxic condition at 45 min. This was concurrent with a substantially increased blood lactate concentration, which reflects an accelerated rate of anaerobic glycolysis. Hypoxia elevated FDG uptake above control by 70% in heart, but not in limbs (representing primarily skeletal muscle), brain, and liver. This study provides the first human evidence for the hypoxia-stimulated glucose uptake in heart. At this hypoxia level, the previously observed hypoxia-stimulated glucose uptake in rat skeletal muscle was not confirmed in the human study.
Relation:	HIGH ALTITUDE MEDICINE & BIOLOGY 10(1)83 ~86
Appears in Collections:	[Department of Physical Therapy, Graduate Institute of Rehabilitation Science] Journal articles

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