Plasma interleukin-1b, -6, -8 and tumor necrosis factor-a as

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Title:	Plasma interleukin-1b, -6, -8 and tumor necrosis factor-a as
Authors:	李順安(Shun-An Lee);蔡秀庭(Hsiu-Ting Tsai);歐秀中(Hsiu-Chung Ou);韓志平(Chih-Ping Han);鄭義銅(Yi-Torng Tee);陳億乘(Yi-Chen Chen);吳明蒼(Ming-Tsang Wu);周明智(Ming-Chin Chou);王博輝(Po-Hui Wang);楊順發(Shun-Fa Yang)*
Contributors:	健康照護學院物理治療學系
Keywords:	proinflammatory cytokines
Date:	2008-07
Issue Date:	2009-08-26 15:55:23 (UTC+8)
Abstract:	Background: The role of proinflammatory cytokines in pelvic inflammatory disease (PID) is unclear. We therefore determined whether plasma proinflammatory cytokines, interleukin-1β (IL-1β), IL-6, IL-8 and tumor necrosis factor-α (TNF-α) were useful plasma markers in PID patients. Methods: Multiplex bead array analysis was used to measure the plasma levels of proinflammatory cytokines in 50 healthy controls as well as in 41 PID patients before and after routine protocol treatments. Results: IL-1β, IL-6, IL-8 and TNF-α were significantly elevated in PID patients before antibiotic treatment than after treatment. However, IL-8 was not significantly different between healthy controls and PID patients. The relative increase in ratio of IL-6 was significantly correlated with white blood cell count (r=0.448, p=0.003), neutrophil count (r=0.472, p=0.002) and C-reactive protein level (r=0.412, p=0.008). Conclusions: IL-1β, IL-6, IL-8 and TNF-α may play an important role in the pathogenesis of PID. These biomarkers, particularly IL-6, could be useful adjuncts for the clinical diagnosis of PID. Clin Chem Lab Med 2008;46:997–1003. [ABSTRACT FROM AUTHOR]
Relation:	CLINICAL CHEMISTRY AND LABORATORY MEDICINE 46(7 )997 ~1003
Appears in Collections:	[Department of Physical Therapy, Graduate Institute of Rehabilitation Science] Journal articles

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