Enhancement of Vascular Function Mediated by Insulin and Insulin-like Growth Factor-1 following Single Exercise Session

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 健康照護學院 > 物理治療學系(停用) > 期刊論文 > Item 310903500/6588

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题名:	Enhancement of Vascular Function Mediated by Insulin and Insulin-like Growth Factor-1 following Single Exercise Session
作者:	(Ai-Lun Yang);(Chia-Ting Su);(Ko-Long Lin);李信達(Shin-Da Lee)*
贡献者:	健康照護學院物理治療學系
日期:	2008-04
上传时间:	2009-08-26 15:55:05 (UTC+8)
摘要:	Exercise is well-known in improving vascular functions, but the underlying mechanism has not been totally understood. The aim of this study was to examine whether single exercise session acutely enhances insulin-induced and insulin-like growth factor-1 (IGF-1)-induced vasorelaxation. Twenty-four male Wistar rats at age of 12 weeks were randomly divided into two groups, control (n = 12) and exercise (n = 12) group. The exercise group ran on a treadmill at a speed of 18 m/min for 60 min. Immediately after exercise, insulin-induced and IGF-1-induced vasorelaxant responses were evaluated by the isometric tension of aortic rings in the organ baths. The roles of phosphatidylinositol 3-kinase (PI3K) and nitric oxide synthase (NOS) in vasorelaxant responses were examined by treating selective inhibitors, such as wortmannin (an inhibitor of PI3K) and N(omega)-nitro-L-arginine methyl ester (L-NAME, a NOS inhibitor). In addition, the vascular responses to sodium nitroprusside (SNP), a NO donor, were examined. We found that single exercise session significantly enhanced vasorelaxation mediated by insulin and IGF-1 in rat aortas (P < 0.01). Also, the exercise-enhanced vasorelaxation was abolished by wortmannin or L-NAME. There was no significant difference of SNP-induced vasorelaxation between control and exercise groups. These results indicate that single exercise session acutely enhances insulin-induced and IGF-1-induced vasorelaxation through the PI3K-NOS-dependent pathway.
關聯:	CHINESE JOURNAL OF PHYSIOLOGY 51(2)71 ~77
显示于类别:	[物理治療學系(停用)] 期刊論文

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