Apolipoprotein E polymorphism in various dementias in Taiwan Chinese population

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 健康照護學院 > 物理治療學系(停用) > 期刊論文 > Item 310903500/6583

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题名:	Apolipoprotein E polymorphism in various dementias in Taiwan Chinese population
作者:	黃雪美(Huang HM);郭宇民(Kuo YM);歐秀中(Hsiu-Chung Ou);林西西(Lin CC);卓良珍(Chuo LJ)*
贡献者:	健康照護學院物理治療學系
关键词:	Apolipoprotein E;polymorphism;dementia;Alzheimer's disease
日期:	2002-11
上传时间:	2009-08-26 15:55:01 (UTC+8)
摘要:	To verify the association between APOE4 frequency and various dementias in Taiwan Chinese individuals, APOE genotypes were determined in patients with dementia of Alzheimer's type (AD), vascular dementia (VD), dementias due to other general medical conditions (OD), and dementia of Alzheimer's type with cerebral vascular disease (mixed type dementia; MD). Only AD patients exhibited higher APOE4 frequency (OR = 2.95, p = 0.001) than controls after Bonferroni correction to control the overall type I error rate for the multiple testing. No such difference was observed among VD, OD, MD and control groups. The lack of association between VD and APOE4 allele frequency suggests that APOE4 allele does not associate with cerebrovascular pathology related dementia in Taiwan Chinese.
關聯:	JOURNAL OF NEURAL TRANSMISSION 11(109 )1415 ~1421
显示于类别:	[物理治療學系(停用)] 期刊論文

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