Proliferative effects of chishao on Schwann cells are FGF-uPA, and ERK- and JNK-dependent

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 健康照護學院 > 物理治療學系(停用) > 期刊論文 > Item 310903500/6578

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題名:	Proliferative effects of chishao on Schwann cells are FGF-uPA, and ERK- and JNK-dependent
作者:	(Kun Shan Huang);(Min-Jin Lu);陳悅生(Yueh-Sheng Chen);蔡輔仁(Fuu-Jen Tsai);郭薇雯(Wei-Wen Kuo);(Yi-Chang Cheng);林建仲(Chien-Chung Lin);蔡長海(Chang-Hai Tsai);黃志揚(Chih-Yang Huang);(Jaung-Geng Lin);歐秀中(Hsiu-Chung Ou)*
貢獻者:	健康照護學院物理治療學系
日期:	2009
上傳時間:	2009-08-26 15:54:57 (UTC+8)
摘要:	This study evaluated the proliferative effects of chishao on RSC96, Schwann cells. A dose-dependent proliferative effect of chishao was obtained by methylthiazol tetrazolium (MTT), proliferating cell nuclear antigen (PCNA) Western blotting, and wound healing assays in Schwann cells administered with chishao (0-500 mg/ml), except at 500 mg/ml concentration. The chishao-treated cells also showed a dose-dependent activated fibroblast growth factor-2 (FGF-2) signaling with increased urokinase plasminogen activator (uPA) and decreased plasminogen activator inhibitor-1 (PAI-1), enhanced proliferative proteins, extracellular signal regulated kinase (ERK) and c-Jun N-terminal kinase (JNK)-signaling. Using mitogen-actvated protein kinase (MAPK)-signaling chemical inhibitors, U0126, SB203580, and SP600125, the proliferative effects of chishao on RSC cells were identified to be ERK- and JNK- signaling dependent. Based on the results, applying appropriate doses of chishao to Schwann cells would be a potential approach for enhancing neuron regeneration.
關聯:	AMERICAN JOURNAL OF CHINESE MEDICINE37(6):1191-202
顯示於類別:	[物理治療學系(停用)] 期刊論文

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