Antinociceptive effect of a novel long-acting nalbuphine preparation

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Title:	Antinociceptive effect of a novel long-acting nalbuphine preparation
Authors:	(Liu KS);(Hu OY);(Ho ST);(Tzeng JI);陳郁文(Yu-Wen Chen);(Wang JJ)*
Contributors:	健康照護學院物理治療學系
Keywords:	analgesics opioid；nalbuphine；nerve；long‐acting antinociception
Date:	2004-05
Issue Date:	2009-08-26 15:54:49 (UTC+8)
Abstract:	"BACKGROUND: A long-acting analgesic may be particularly desirable in patients suffering from long-lasting pain. The aim of the study was to evaluate the antinociceptive effect of a novel nalbuphine preparation and to determine its duration of action. METHODS: The antinociceptive effects of i.m. nalbuphine HCl in saline and nalbuphine base in sesame oil were evaluated in rats. The in vitro drug-releasing profiles of nalbuphine HCl and base in different preparations were also evaluated. RESULTS: We found that i.m. nalbuphine HCl 25, 50 and 100 micromol kg(-1) produced dose-related antinociceptive effects with a duration of action of 1.5, 2 and 3 h, respectively. i.m. nalbuphine base 100, 200 and 400 micromol kg(-1) also produced dose-related antinociceptive effects but with longer durations of action: 27, 49 and 55 h, respectively. In vitro studies demonstrated that nalbuphine base in sesame oil had the slowest drug-releasing profile of the different preparations. CONCLUSIONS: i.m. injection of an oil formulation of nalbuphine base produced a long-lasting antinociceptive effect."
Relation:	BRITISH JOURNAL OF ANAESTHESIA 92(5 )712 ~715
Appears in Collections:	[Department of Physical Therapy, Graduate Institute of Rehabilitation Science] Journal articles

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