Exercise and Rest Technetium-99m-Tetrofosmin Lung Uptake: Correlation with Left Ventricular Ejection Fraction in Patients with Coronary Artery Disease

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Title:	Exercise and Rest Technetium-99m-Tetrofosmin Lung Uptake: Correlation with Left Ventricular Ejection Fraction in Patients with Coronary Artery Disease
Authors:	(Shi-Sheng Tsou);孫盛生(Shung-Shung Sun);高嘉鴻(Chia-Hung Kao);林正介(Cheng-Chieh Lin);李正淳(Cheng-Chun Lee)
Contributors:	健康照護學院生物醫學影像暨放射科學學系;中國附醫核子醫學科
Date:	2002
Issue Date:	2009-08-26 15:53:45 (UTC+8)
Abstract:	Increased lung uptake of thallium-201 (Tl-201) and technetium-99m (Tc-99m) MIBI in myocardial perfusion imaging is a reliable marker of left ventricular dysfunction. The goal of our study was to establish whether the lung-to-heart (L/H) uptake ratio with a newer cardiac imaging agent, Tc-99m tetrofosmin, can also provide valuable information about left ventricular function. We studied 60 patients with recent coronary artery diseases (CAD) undergoing first-pass radionuclide ventriculography to calculate left ventricular ejection fraction (LVEF) and myocardial perfusion imaging to calculate the L/H ratio. Group A consisting of 30 CAD patients with higher LVEF (> or =40%) had a significantly lower L/H ratio than group B consisting of 30 CAD patients with abnormal LVEF (<40%) during exercise and rest. In groups A and B, the exercise and rest L/H ratios did not differ significantly. However, a statistically significant inverse correlation was found between the L/H ratio and LVEF during exercise and rest among the 60 patients. L/H ratios, measured by 99mTc-tetrofosmin imaging, provide clinically useful information with which to predict left ventricular dysfunction in CAD patients.
Relation:	JAPANESE HEART JOURNAL 43(5)515 ~522
Appears in Collections:	[Department of Biomedical Imaging and Radiological Science] Journal articles

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