Ellagic acid inhibited 2-aminofluorene and p-aminobenzoic acid acetylation by mononuclear leukocytes from Sprague-Dawley rats.

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Title:	Ellagic acid inhibited 2-aminofluorene and p-aminobenzoic acid acetylation by mononuclear leukocytes from Sprague-Dawley rats.
Authors:	(Chin-Chin Ho)、(Huei-Yann Tsai)、(Yi-Shyong Lai)、鍾景光(Jing-Gung Chung)*
Contributors:	生命科學院生物科技學系;中國附醫醫學研究部
Date:	2001.03
Issue Date:	2009-08-25 14:40:22 (UTC+8)
Abstract:	Following exposure of rats to the arylamine carcinogen 2-aminofluorene, DNA-carcinogen adducts were found in the liver and bladder target tissues, and also in circulating leucocytes. This work investigated the effect of ellagic acid on arylamine (2-aminofluorene and p-aminobenzoic acid) acetylations in rat leucocytes. Evidence is presented that rat mononuclear leucocytes are capable of acetylating 2-aminofluorene and p-aminobenzoic acid. Both lymphocytes and monocytes were able to acetylate arylamines during 18 h of culture. Cultured lymphocytes produced about twice as much N-acetyl-2-aminofluorene from 2-aminofluorene and 2.2-fold as much N-acetyl-p-aminobenzoic acid from p-aminobenzoic acid as monocytes. After cotreatment with ellagic acid the lymphocyte and monocyte cultures indicated that ellagic acid reduced 2-aminofluorene acetylation.
Relation:	Cytobios 104(406 )107 ~117
Appears in Collections:	[Department of Biological Science and Technology] Journal articles

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