Effeacts of curcumin on N-bis( 2-Hydroxypropyl )nitrosamine (DHPN)-induced lung and liver tumorigenesis in BALB/c mice in vivo

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Title:	Effeacts of curcumin on N-bis( 2-Hydroxypropyl )nitrosamine (DHPN)-induced lung and liver tumorigenesis in BALB/c mice in vivo
Authors:	黃安正(AN-CHENG HUANG)、林淑媛(SHUW-YUAN LIN)、蘇進成(Chin-Cheng Su)、林松水(SONG-SHEI LIN)、何蓁蓁(CHIN-CHIN HO)、夏德椿(Te-Chun Hsia)、邱燦宏(Tsan-Hung Chiu)、游春淑(chun shu yu)、葉兆雲(Ip Siu-Wan)、林宗平、鍾景光(Jing-Gung Chung)*
Contributors:	生命科學院生物科技學系;中國附醫醫學研究部
Keywords:	Curcumin;DHPN (N-bis(2-hydroxypropyl)nitrosamine;tumorigenesis BALB/c mice;in vivo
Date:	2008.12
Issue Date:	2009-08-25 14:40:04 (UTC+8)
Abstract:	Curcumin (diferuloylmethane), a phenolic compound from the plant Curcuma longa (Linn.) has been shown to exhibit antitumor activity and apoptosis in many human cancer cell lines including that of lung and liver cancer. In this study, curcumin was evaluated in BALB/c mice for its ability to inhibit pulmonary and liver adenoma formation and growth after they were orally treated with N-bis(2-hydroxy-propyl)nitrosamine (DHPN). Animals were treated with DHPN in water for approximately 14 days before multiple doses of curcumin were given intraperitoneally. It was found that 200 μM curcumin reduced lung and liver tumor multiplicity by 37% (p<0.05) and 30% (p<0.05) respectively. The results indicated that curcumin significantly inhibited pulmonary and liver adenoma formation and growth in BALB/c mice. The precise mechanism by which curcumin inhibits lung and liver tumorigenesis remains to be elucidated. Thus, curcumin appears to be a promising new chemotherapeutic and preventive agent for lung and liver cancer induced by DHPN.
Relation:	IN VIVO 22:781 ~786
Appears in Collections:	[Department of Biological Science and Technology] Journal articles

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