Curcumin inhibits WEHI-3 leukemia cells in BALB/c mice in vivo

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 生命科學院 > 生物科技學系暨碩士班 > 期刊論文 > Item 310903500/6294

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题名:	Curcumin inhibits WEHI-3 leukemia cells in BALB/c mice in vivo
作者:	蘇進誠(Su CC)、楊家欣(Yang Jai-Sing)、林淑媛(Lin SY)、呂旭峰(Lu HF)、林松水(Lin SS)、張永賢(Yung-Hsien Chang)、黃雯雯(Wenwen Huang)、李玉菁(Li YC)、張淑貞(Shu-Jen Chang)、鍾景光(Jing-Gung Chung)*
贡献者:	生命科學院生物科技學系;中國附醫醫學研究部
关键词:	Curcumin;WEHI-3;leukemia cells;BALB/c mice;cytotoxicity
日期:	2008.01
上传时间:	2009-08-25 14:40:01 (UTC+8)
摘要:	Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), a natural polyphenol product of the plant Curcuma longa, exhibited potent inhibitory activities against proliferation, induced cell cycle arrest and exhibited the induction of apoptosis in several tumor cell lines. In our previous studies, we have shown that curcumin induced cell cycle arrest and apoptosis on human leukemia HL-60 and mouse leukemia WEHI-3 cells; there are no reports regarding whether or not it affects leukemia cells in vivo. In the present study, we investigated the effects of curcumin on WEHI-3 in BALB/c mice and the results indicated that curcumin reduces the percentage of Mac-3 marker, which is the precursor of macrophage. Curcumin induced significant effects on the population of B cells from murine leukemia in vivo. We also investigated the weights of spleen and liver from murine leukemia and the results showed that curcumin reduced the weight of the liver and spleen. From the pathological examinations, the effects of curcumin on the liver and spleen from mice after being injected with WEHI-3 cells were apparent. Both organs were enlarged. In conclusion, curcumin affect WEHI-3 cells in vivo.
關聯:	IN VIVO 22(1 )63 ~68
显示于类别:	[生物科技學系暨碩士班] 期刊論文

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